Wilson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Wilson's Disease, including details on treatment, causes, symptoms, medication.

Copper:caeruloplasmin ratio.

Twomey PJ, Viljoen A, House IM, Reynolds TM, Wierzbicki AS

Department of Clinical Biochemistry, The Ipswich Hospital, Ipswich, UK. patrick.twomey@ipswichhospital.nhs.uk

Investigation of copper status can be a diagnostic challenge. The non-caeruloplasmin-bound copper (NCC) has deficiencies; accordingly, the copper:caeruloplasmin ratio has been suggested as an alternative index of copper status. A reference interval for this index was derived. In addition to making the interpretation of copper easier, the copper:caeruloplasmin ratio should also enable adjustment for relatively high caeruloplasmin concentrations without recourse to producing gender- and age-derived intervals. The copper:caeruloplasmin ratio has weaknesses similar to those identified for NCC in that immunological methods used for caeruloplasmin can cross react with apocaeruloplasmin and there is no standardised method for caeruloplasmin. Caeruloplasmin assays also have uncertainty from precision, bias and specificity and, accordingly, method-related differences may have a large effect on the copper:caeruloplasmin ratio in a manner similar to the NCC.

Published 4 April 2007 in J Clin Pathol, 60(4): 441-2.
Full-text of this article is available online (may require subscription).

© 2005-2008 Wilson's Disease Research Today. All Rights Reserved.